Cerebral circulation time derived from fMRI signals in large blood vessels.

ABSTRACT:

Background

The systemic low-frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information.

Purpose

1) To further develop and validate a method utilizing these signals to measure the delay times from the ICAs and the SSS. 2) To establish the delay time as an effective perfusion biomarker that associates with cerebral circulation time (CCT). 3) To explore within subject variations, and the effects of gender and age on the delay times.

Study type

Prospective.

Subjects

In all, 100 healthy adults (Human Connectome Project [HCP], age range 22-36 years, 54 females and 46 males), 56 healthy children (Adolescent Brain Cognitive Development

SUBMITTER: Yao JF 

PROVIDER: S-EPMC7171696 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature