Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpectedly high frequency of central nervous system involvement, even in patients with asymptomatic SLE. The purpose of this study was to identify early signs of retinal neurodegeneration by comparing the thickness of the peripapillary retinal nerve fiber layer (pRNFL) and all macular layers between patients with SLE without ophthalmologic manifestations and healthy controls. The effect of disease duration and systemic comorbidities was also studied.

Methods

Cross-sectional study, in which all participants underwent a complete ophthalmologic evaluation including retinal segme

SUBMITTER: Dias-Santos A 

PROVIDER: S-EPMC7171841 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature