Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.

ABSTRACT:

Background

Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive. The DLG2 gene resides in the 11q-deleted region, thus makes it an interesting NB candidate tumor suppressor gene.

Methods

We evaluated the association of DLG2 gene expression in NB with patient outcomes, stage and MYCN status, using online microarray data combining independent NB patient data sets. Functional studies were also conducted using NB cell models and the fruit fly.

Results

Using the array data we concluded that higher DLG2 expression was positively correlated to patient survival. We could also see that expression of DLG2

SUBMITTER: Keane S 

PROVIDER: S-EPMC7171851 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature