Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.

ABSTRACT:

Background

Circular RNAs are non-coding RNA molecules with gene regulatory potential that have been associated with several human diseases. They are stable and present in the circulation, making them excellent candidates for biomarkers of disease. Despite their promise as biomarkers or future therapeutic targets, information on their expression and functionality in human pancreatic islets is a relatively unexplored subject.

Methods

Here we aimed to produce an enriched circRNAome profile for human pancreatic islets by CircleSeq, and to explore the relationship between circRNA expression, diabetes status, genotype at T2D risk loci and measures of glycaemia (insulin secretory index; SI and HbA1c) in human islet preparations from healthy control donors and donors with type 2 dia

SUBMITTER: Haque S 

PROVIDER: S-EPMC7171860 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature