Brain-derived neurotrophic factor levels in pediatric sickle cell disease.

ABSTRACT:

Background

Children with sickle cell disease (SCD) have an increased risk of neurological complications, particularly stroke and silent cerebral infarction (SCI). Brain-derived neurotrophic factor (BDNF) is a nerve growth factor associated with neuronal survival, synaptic plasticity, elevated transcranial Doppler (TCD) velocities and increased risk of stroke in patients with SCD. The objective of this study was to analyze plasma BDNF protein levels in children with SCD participating in the Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial (SIT Trial), comparing plasma samples of children with SCD and SCI to plasma samples from children with SCD without SCI, as well as healthy pediatric control participants.

Procedure

Entry, exit, and longitudinal blood samples

SUBMITTER: Lance EI 

PROVIDER: S-EPMC7171877 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature