Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice.

ABSTRACT: During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially important. To address this and find plasma biomarkers to assess ionizing radiation-induced mortality in the early stages, mice were administered a whole-body lethal dose of γ radiation, and radiation-induced damage was evaluated. Multiple blood biomarkers were screened using an antibody array, followed by validation using enzyme-linked immunoassay. The results revealed that irradiation (IR)-induced mortality in mice and caused body weight and blood platelet losses in deceased mice compared to surviving mice. The levels of certain proteins d

SUBMITTER: Fu H 

PROVIDER: S-EPMC7171989 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature