Forced conceptual thought induced by electrical stimulation of the left prefrontal gyrus involves widespread neural networks.

ABSTRACT:

Background

Early accounts of forced thought were reported at the onset of a focal seizure, and characterized as vague, repetitive, and involuntary intellectual auras distinct from perceptual or psychic hallucinations or illusions. Here, we examine the neural underpinnings involved in conceptual thought by presenting a series of 3 patients with epilepsy reporting intrusive thoughts during electrical stimulation of the left lateral prefrontal cortex (PFC) during invasive surgical evaluation. We illustrate the widespread networks involved through two independent brain imaging modalities: resting state functional magnetic resonance imaging (fMRI) (rs-fMRI) and task-based meta-analytic connectivity modeling (MACM).

Methods

We report the clinical and stimulation characteristics of

SUBMITTER: Liu A 

PROVIDER: S-EPMC7172015 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature