General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.

ABSTRACT: Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7172026 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature