Resveratrol plus carboxymethyl-β-glucan in infants with common cold: A randomized double-blind trial.

ABSTRACT:

Objectives

To evaluate effectiveness of a nasal resveratrol/carboxymethyl-β-glucan solution compared to nasal saline solution: a) on common cold symptoms by means of a validated measure scale (CARIFS score), b) on Rhinovirus infection and CCL2, CCL5, IL8, IL6, CXCL10 and TLR2 expression in nasal swabs, c) on frequency of relapses after 30 days of follow-up.

Methods

89 infants with respiratory infection symptoms were randomly assigned to receive either a nasal resveratrol/carboxymethyl-β-glucan solution or nasal saline solution.All patients were evaluated with CARIFS score at enrollment, after 48 h, 7 and 30 days by physicians and parents. Nasal swabs were obtained at enrollment, after 48 h and after one week.

Results

CARIFS score improved in both groups. Episodes of s

SUBMITTER: Baldassarre ME 

PROVIDER: S-EPMC7172624 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature