Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.

ABSTRACT:

Introduction

Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors including reduced birth weight, excess adiposity, and dyslipidemia. Identifying the metabolic changes induced by PFAS exposure could enhance our understanding of biological pathways underlying PFAS toxicity.

Objective

To identify metabolic alterations associated with serum concentrations of four PFAS in children using a metabolome-wide association study.

Methods

We performed untargeted metabolomic profiling by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified serum concentrations of perfluorooctanoic acid, perfluoroo

SUBMITTER: Kingsley SL 

PROVIDER: S-EPMC7172933 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature