Conservation and divergence of related neuronal lineages in the Drosophila central brain.

ABSTRACT: Wiring a complex brain requires many neurons with intricate cell specificity, generated by a limited number of neural stem cells. Drosophila central brain lineages are a predetermined series of neurons, born in a specific order. To understand how lineage identity translates to neuron morphology, we mapped 18 Drosophila central brain lineages. While we found large aggregate differences between lineages, we also discovered shared patterns of morphological diversification. Lineage identity plus Notch-mediated sister fate govern primary neuron trajectories, whereas temporal fate diversifies terminal elaborations. Further, morphological neuron types may arise repeatedly, interspersed with other types. Despite the complexity, related lineages produce similar neuron types in comparable temporal p

SUBMITTER: Lee YJ 

PROVIDER: S-EPMC7173964 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature