Distinct patterns of structural damage underlie working memory and reasoning deficits after traumatic brain injury.

ABSTRACT: It is well established that chronic cognitive problems after traumatic brain injury relate to diffuse axonal injury and the consequent widespread disruption of brain connectivity. However, the pattern of diffuse axonal injury varies between patients and they have a correspondingly heterogeneous profile of cognitive deficits. This heterogeneity is poorly understood, presenting a non-trivial challenge for prognostication and treatment. Prominent amongst cognitive problems are deficits in working memory and reasoning. Previous functional MRI in controls has associated these aspects of cognition with distinct, but partially overlapping, networks of brain regions. Based on this, a logical prediction is that differences in the integrity of the white matter tracts that connect these networks shou

SUBMITTER: Jolly AE 

PROVIDER: S-EPMC7174032 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature