Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease.

ABSTRACT: There is both clinical and neuroanatomical variability at the single-subject level in Alzheimer's disease, complicating our understanding of brain-behaviour relationships and making it challenging to develop neuroimaging biomarkers to track disease severity, progression, and response to treatment. Prior work has shown that both group-level atrophy in clinical dementia syndromes and complex neurological symptoms in patients with focal brain lesions localize to brain networks. Here, we use a new technique termed 'atrophy network mapping' to test the hypothesis that single-subject atrophy maps in patients with a clinical diagnosis of Alzheimer's disease will also localize to syndrome-specific and symptom-specific brain networks. First, we defined single-subject atrophy maps by comparing corti

SUBMITTER: Tetreault AM 

PROVIDER: S-EPMC7174048 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature