Multifaceted effects of soluble human CD6 in experimental cancer models.

ABSTRACT:

Background

CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse. There, CD6 assists in cell-to-cell contact stabilization and modulation of activation/differentiation events through interaction with CD166/ALCAM (activated leukocyte cell adhesion molecule), its main reported ligand. While accumulating evidence is attracting new interest on targeting CD6 for therapeutic purposes in autoimmune disorders, little is known on its potential in cancer. In an attempt to elucidate the in vivo relevance of blocking CD6-mediated interactions in health and disease, we explored the consequences of expressing high circulating levels of a soluble form CD6 (sCD6) as a decoy receptor.

Methods

High s

SUBMITTER: Simoes IT 

PROVIDER: S-EPMC7174071 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature