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ABSTRACT:
SUBMITTER: Jakobsson JE
PROVIDER: S-EPMC7174138 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Jakobsson Jimmy E JE Lu Shuiyu S Telu Sanjay S Pike Victor W VW
Angewandte Chemie (International ed. in English) 20200310 18
Herein, the synthesis and use of [<sup>11</sup> C]carbonyl difluoride for labeling heterocycles with [<sup>11</sup> C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [<sup>11</sup> C]carbon monoxide into [<sup>11</sup> C]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broad range of cyclic substrates, for example, imidazolidin-2-ones, thiazolidin-2-ones, and oxaz ...[more]