[¹¹ C]Carbonyl Difluoride-a New and Highly Efficient [¹¹ C]Carbonyl Group Transfer Agent.

ABSTRACT: Herein, the synthesis and use of [¹¹ C]carbonyl difluoride for labeling heterocycles with [¹¹ C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [¹¹ C]carbon monoxide into [¹¹ C]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broad range of cyclic substrates, for example, imidazolidin-2-ones, thiazolidin-2-ones, and oxazolidin-2-ones. Labeling reactions may utilize close-to-stoichiometric precursor quantities and short reaction times at room temperature in a wide range of solvents while also showing high water tolerability. The overall radiosynthesis protocol is both simple and reproducible. The required apparatus

SUBMITTER: Jakobsson JE 

PROVIDER: S-EPMC7174138 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature