Innovations in structure-based antigen design and immune monitoring for next generation vaccines.

ABSTRACT: The recent explosion of atomic-level structures of glycoproteins that comprise the surface antigens of human enveloped viruses, such as RSV, influenza, and HIV, provide tremendous opportunities for rational, structure-based vaccine design. Several concepts in structure-based vaccine design have been put into practice and are are well along preclinical and clinical implementation. Testing of these designed immunogens will provide key insights into the ability to induce the desired immune responses, namely neutralizing antibodies. Many of these immunogens in human clinical trials represent only the first wave of designs and will likely require continued tweaking and elaboration to achieve the ultimate goal of enhanced breadth and potency. Considerable effort is now being invested in germline

SUBMITTER: Ward AB 

PROVIDER: S-EPMC7174181 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature