Pitfalls in quantitative myocardial PET perfusion II: Arterial input function.

ABSTRACT:

Rationale

We aimed to define the impact of variable arterial input function on myocardial perfusion severity that may misguide interventional decisions and relates to limited capacity of 3D PET for high-count arterial input function of standard bolus R-82.

Methods

We used GE Discovery-ST 16 slice PET-CT, serial 2D and 3D acquisitions of variable Rb-82 dose in a dynamic circulating arterial function model, static resolution and uniformity phantoms, and in patients with dipyridamole stress to quantify per-pixel rest and stress cc·min^-1·g^-1, CFR and CFC with (+) and (-) 10% simulated change in arterial input.

Results

For intermediate, border zone severity of stress perfusion, CFR and CFC comprising 7% of 3987 cases, simulated arterial input variabil

SUBMITTER: Bui L 

PROVIDER: S-EPMC7174279 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature