Focal lamina cribrosa defects are not associated with steep lamina cribrosa curvature but with choroidal microvascular dropout.

ABSTRACT: Focal lamina cribrosa (LC) defects have been found to play an important role in the development and progression of glaucomatous optic neuropathy. However, the mechanism of generation of focal LC defects is largely unknown. This cross-sectional study was performed to investigate LC curvature and the frequency of parapapillary choroidal microvascular dropout (MvD) in glaucomatous eyes with focal LC defects. This study was conducted by a retrospective review of patients with primary open-angle glaucoma (POAG) included in an ongoing prospective study being performed at the Seoul National University Bundang Hospital (Investigating Glaucoma Progression Study). A total of 118 eyes of 118 patients with POAG, 59 with and 59 without focal LC defects, with eyes matched by age, axial length, and sever

SUBMITTER: Lee SH 

PROVIDER: S-EPMC7174329 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature