Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.

ABSTRACT: Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5-20%, even while under specific treatment. In humans and other species susceptible to fatal VL, such as dogs and hamsters, the disruption of splenic white pulp (WP) is accompanied by disease progression. Control of VL progression is seen in BALB/c mice, as evidenced by a mild clinical presentation and controlled parasite replication in the liver and spleen. In this study, we investigated the features involved in the morphological remodeling of splenic compartments associated with the control of VL progression to death. Methods: We evaluated cohorts of BAL

SUBMITTER: de Melo CVB 

PROVIDER: S-EPMC7174685 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature