The Multi-Faced Extracellular Vesicles in the Plasma of Chronic Kidney Disease Patients.

ABSTRACT: Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cells in body fluids and extracellular matrix. They function as signal transducers in intercellular communication, contributing to the maintenance of cell and tissue integrity. EVs biogenesis is deregulated in various pathologies, in structural and functional connection to the pathophysiology of donor cells. Consequently, EVs are considered diagnostic and monitoring factors in many diseases. Despite consensus as to their activity in promoting coagulation and inflammation, there is evidence suggesting protective roles for EVs in stress states. Chronic kidney disease (CKD) patients are at high risk of developing cardiovascular defects. The pathophysiology, comorbidities, and treatment of CKD may individually an

SUBMITTER: Georgatzakou HT 

PROVIDER: S-EPMC7174738 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature