Ontology highlight
ABSTRACT:
SUBMITTER: Andrieu C
PROVIDER: S-EPMC7174838 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Andrieu Cyril C Montigny Audrey A Bibonne Anne A Despin-Guitard Evangeline E Alfandari Dominique D Théveneau Eric E
Development (Cambridge, England) 20200412 7
Matrix metalloproteinases have a broad spectrum of substrates ranging from extracellular matrix components and adhesion molecules to chemokines and growth factors. Despite being mostly secreted, MMPs have been detected in the cytosol, the mitochondria or the nucleus. Although most of the attention is focused on their role in matrix remodeling, the diversity of their substrates and their complex trafficking open the possibility for non-canonical functions. Yet <i>in vivo</i> examples and experime ...[more]