Ontology highlight
ABSTRACT:
SUBMITTER: Garriock RJ
PROVIDER: S-EPMC7174843 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Garriock Robert J RJ Chalamalasetty Ravindra B RB Zhu JianJian J Kennedy Mark W MW Kumar Amit A Mackem Susan S Yamaguchi Terry P TP
Development (Cambridge, England) 20200412 8
Despite the importance of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively little is known about its role in colon formation during embryogenesis. The development of the colon starts with the formation and extension of the hindgut. We show that <i>Wnt3a</i> is expressed in the caudal embryo in a dorsal-ventral (DV) gradient across all three germ layers, including the hindgut. Using genetic and lineage-tracing approaches, we describe novel dorsal and vent ...[more]