Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice.

ABSTRACT:

Background and purpose

Respiratory viral infections play central roles in the initiation, exacerbation and progression of asthma in humans. An acute paramyxoviral infection in mice can cause a chronic lung disease that resembles human asthma. We sought to determine whether reduction of Sendai virus lung burden in mice by stimulating innate immunity with aerosolized Toll-like receptor (TLR) agonists could attenuate the severity of chronic asthma-like lung disease.

Experimental approach

Mice were treated by aerosol with 1-μM oligodeoxynucleotide (ODN) M362, an agonist of the TLR9 homodimer, and 4-μM Pam2CSK4 (Pam2), an agonist of the TLR2/6 heterodimer, within a few days before or after Sendai virus challenge.

Key results

Treatment with ODN/Pam2 caused ~75% reduction in

SUBMITTER: Goldblatt DL 

PROVIDER: S-EPMC7174884 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature