Ontology highlight
ABSTRACT:
SUBMITTER: Vezzoli E
PROVIDER: S-EPMC7174989 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Vezzoli E E Calì C C De Roo M M Ponzoni L L Sogne E E Gagnon N N Francolini M M Braida D D Sala M M Muller D D Falqui A A Magistretti P J PJ
Cerebral cortex (New York, N.Y. : 1991) 20200401 4
Long-term memory formation (LTM) is a process accompanied by energy-demanding structural changes at synapses and increased spine density. Concomitant increases in both spine volume and postsynaptic density (PSD) surface area have been suggested but never quantified in vivo by clear-cut experimental evidence. Using novel object recognition in mice as a learning task followed by 3D electron microscopy analysis, we demonstrate that LTM induced all aforementioned synaptic changes, together with an i ...[more]