Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.

ABSTRACT: Calcium oxalate (CaOx) crystal-induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Although CaOx crystallization inhibitors have been suggested as a therapeutic modality already decades ago, limited progress has been made in the discovery of potent molecules with efficacy in animal disease models. Herein, an image-based machine learning approach to systematically screen chemically modified myo-inositol hexakisphosphate (IP6) analogues is utilized, which enables the identification of a highly active divalent inositol phosphate molecule. To date, this is the first molecule shown to completely inhibit the crystallization process in the nanomolar range, reduce crystal-cell interactions, thereby preventing CaOx-induced

SUBMITTER: Kletzmayr A 

PROVIDER: S-EPMC7175250 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature