Biomineral Precursor Formation Is Initiated by Transporting Calcium and Phosphorus Clusters from the Endoplasmic Reticulum to Mitochondria.

ABSTRACT: Mineral granules in the mitochondria of bone-forming cells are thought to be the origin of biomineral precursors, which are transported to extracellular matrices to initiate cell-mediated biomineralization. However, no evidence has revealed how mitochondrial granules form. This study indicates that mitochondrial granules are initiated by transporting calcium and phosphorus clusters from the endoplasmic reticulum (ER) to mitochondria based on detailed observations of the continuous process of mouse parietal bone development as well as in vitro biomineralization in bone-forming cells. Nanosized biomineral precursors (≈30 nm in diameter), which originate from mitochondrial granules, initiate intrafibrillar mineralization of collagen as early as embryonic day 14.5. Both in vivo and in vitro st

SUBMITTER: Tang C 

PROVIDER: S-EPMC7175271 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature