Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase.

ABSTRACT: The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating in the regulation of cellular proliferation and differentiation. In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known. In bacteria, plants, and fungi Put is synthesized also from agmatine, which is formed from L-arginine by arginine decarboxylase (ADC). Here we demonstrate that the isosteric hydroxylamine analogue of agmatine (AO-Agm) is a new and very potent (IC₅₀ 3•10^-8 M) inhibitor of E. coli ADC. It was almost two orders of magnitude less potent toward

SUBMITTER: Hyvonen MT 

PROVIDER: S-EPMC7175277 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature