Adsorption of Fibrinogen on Silica Surfaces-The Effect of Attached Nanoparticles.

ABSTRACT: When a biomaterial is inserted into the body, proteins rapidly adsorb onto its surface, creating a conditioning protein film that functions as a link between the implant and adhering cells. Depending on the nano-roughness of the surface, proteins will adsorb in different amounts, with different conformations and orientations, possibly affecting the subsequent attachment of cells to the surface. Thus, modifications of the surface nanotopography of an implant may prevent biomaterial-associated infections. Fibrinogen is of particular importance since it contains adhesion epitopes that are recognized by both eukaryotic and prokaryotic cells, and can therefore influence the adhesion of bacteria. The aim of this study was to model adsorption of fibrinogen to smooth or nanostructured silica surfa

SUBMITTER: Hyltegren K 

PROVIDER: S-EPMC7175343 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature