Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes.

ABSTRACT: Dopamine (DA) is a monoamine neurotransmitter responsible for the maintenance of a variety of vital life functions. In vivo DA signaling occurs over multiple time scales, from subsecond phasic release due to dopamine neuron firing to tonic release responsible for long-term DA concentration changes over minutes to hours. Due to the complex, multifaceted nature of DA signaling, analytical sensing technology must be capable of recording DA from multiple locations and over multiple time scales. Decades of research has focused on improving in vivo detection capabilities for subsecond phasic DA, but the accurate detection of absolute resting DA levels in real time has proven challenging. We have developed a poly(3,4-ethylenedioxythiophene) (PEDOT)-based nanocomposite coating that exhibits excell

SUBMITTER: Taylor IM 

PROVIDER: S-EPMC7175412 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature