Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer.

ABSTRACT:

Background

Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. On the other hand, defective mismatch repair (dMMR) tumors, primarily located in the right colon, are known to have favorable survival and dense local immune infiltration. The aim of this study was to see if there is any form of relationship between these seemingly diverse entities.

Methods

Complete clinical and long-term survival data were retrieved for 316 CRC patients operated at Helsinki University Hospital between the years 1998 and 2003. Tissue microarrays were prepared from surgical specimens and further processed and analyzed for local immune cell infiltration using m

SUBMITTER: Gunnarsson U 

PROVIDER: S-EPMC7175507 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature