Progressive multifocal leukoencephalopathy in a patient post allo-HCT successfully treated with JC virus specific donor lymphocytes.

ABSTRACT:

Background

Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder. Reactivation of John Cunningham virus leads to oligodendrocyte infection with lysis and consequent axonal loss due to demyelination. Patients usually present with confusion and seizures. Late diagnosis and lack of adequate therapy options persistently result in permanent impairment of brain functions. Due to profound T cell depletion, impairment of T-cell function and potent immunosuppressive factors, allogeneic hematopoietic cell transplantation recipients are at high risk for JCV reactivation. To date, PML is almost universally fatal when occurring after allo-HCT.

Methods

To optimize therapy specificity, we enriched JCV specific T-cells out of the donor T-cell repertoire from the HLA-ide

SUBMITTER: Steinhardt MJ 

PROVIDER: S-EPMC7175555 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature