Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes.

ABSTRACT:

Background

Keloids are benign fibroproliferative skin lesions that are difficult to treat and become a lifetime predicament for patients. Several treatment modalities have been put forth, but as yet no satisfactory approach to the prevention or treatment of keloids has been identified. The process of epithelial-to-mesenchymal transition (EMT) has been implicated in keloid scarring, as keloid keratinocytes display an EMT-like phenotype. This study investigated the potential of pirfenidone, an antifibrotic agent, to counteract EMT-like alterations in keloid keratinocytes, including gene expression, cell migratory and proliferative functions.

Methods

Normal and keloid keratinocytes were isolated from discarded normal skin tissues and from resected keloid tissues, respectively.

SUBMITTER: Satish L 

PROVIDER: S-EPMC7175767 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature