Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia.

ABSTRACT:

Background

Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients the disease progresses to critical limb ischaemia (CLI). In a substantial number of patients with CLI, no effective treatment option other than amputation is available and around a quarter of these patients will require a major amputation during the following year. This is an update of the review first published in 2011.

Objectives

To determine the effectiveness and safety of local intramuscular transplantation of autologous adult bone marrow mononuclear cells (BMMNCs) as a treatment for critical limb ischaemia (CLI).

Search methods

For this update the Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched

SUBMITTER: Moazzami K 

PROVIDER: S-EPMC7175832 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature