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A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia.

ABSTRACT: A 69-year-old right-handed woman developed difficulty naming objects and word-finding. The clinical features of language disorder and predominant atrophy on MRI and predominant hypoperfusion on ¹²³I-IMP SPECT in the left temporo-parietal junction area were consistent with the diagnostic criteria for the logopenic variant of primary progressive aphasia (lvPPA). Neurological examination showed slight right-side rigidity and resting tremor (UPDRS-III: 4). ¹²³I-FP-CIT SPECT showed presynaptic dopamine transporter reduction in the posterior putamina with left-side predominance. The odor-stick identification test for Japanese exhibited complete loss of the sense of smell (anosmia). These findings suggest that lvPPA may be accompanied by parkinsonism and anosmia.

SUBMITTER: Sasaki S

PROVIDER: S-EPMC7175926 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia.

Sasaki Shoichi S

Journal of Alzheimer's disease reports 20200311 1

A 69-year-old right-handed woman developed difficulty naming objects and word-finding. The clinical features of language disorder and predominant atrophy on MRI and predominant hypoperfusion on <sup>123</sup>I-IMP SPECT in the left temporo-parietal junction area were consistent with the diagnostic criteria for the logopenic variant of primary progressive aphasia (lvPPA). Neurological examination showed slight right-side rigidity and resting tremor (UPDRS-III: 4). <sup>123</sup>I-FP-CIT SPECT sho ...[more]

PMID: 32328564

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