Sarcopenia and Variation in the Human Leukocyte Antigen Complex.

ABSTRACT:

Background

Aging is characterized by chronic inflammation plus loss of muscle mass and strength, termed sarcopenia. Human leukocyte antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants are associated with sarcopenia in autoimmune disease-free older people.

Methods

Data were collected from 181,301 UK Biobank European descent volunteers aged 60-70 with measured hand grip strength and impedance. Logistic regression analysis estimated HLA type and sarcopenia associations, adjusted for confounders and multiple testing.

Results

Having any autoimmune diagnosis was associated with sarcopenia (odds ratio [OR] 1.83, 95% co

SUBMITTER: Jones G 

PROVIDER: S-EPMC7176057 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature