Telomeres Increasingly Develop Aberrant Structures in Aging Humans.

ABSTRACT: Telomeres progressively shorten with age, and it has been proposed that critically short and dysfunctional telomeres contribute to aging and aging-associated diseases in humans. For many years it was thought that telomere erosion was strictly a consequence of the "end replication problem," or the inability of replicative polymerases to completely duplicate linear DNA ends. It is becoming increasingly evident, however, that telomere shortening of cultured human cells is also caused because of other replication defects in telomeric repeats, those that cause fragile telomeres and other aberrant telomeric structures that can be detected on metaphase chromosomes. Whether these replication defects contribute to telomere erosion also in human tissues is currently unknown. By analyzing peripheral

SUBMITTER: Boccardi V 

PROVIDER: S-EPMC7176058 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature