Longitudinal Change in Cortisol Levels Across the Adult Life Span.

ABSTRACT:

Background

Cortisol is a key stress hormone implicated in the pathogenesis of many age-related diseases. Longitudinal information on cortisol exposure has been restricted to animal models and a small number of human studies. The purpose of the present study was to quantify longitudinal change in cortisol across the adult life span.

Methods

We conducted a prospective longitudinal study of 24-hour urinary free cortisol excretion from ages 20 to 90 years and older. Participants were 1,814 men and women from the Baltimore Longitudinal Study of Aging who provided a total of 5,527 urine specimens for analysis. The average duration of longitudinal follow-up was 6.6 years. The primary outcome measure was 24-hour urinary free cortisol to creatinine ratio (UFC/Cr) as determined by liq

SUBMITTER: Moffat SD 

PROVIDER: S-EPMC7176109 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature