Ontology highlight
ABSTRACT:
SUBMITTER: Heng J
PROVIDER: S-EPMC7176290 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Heng Jian J Lv Peng P Zhang Yifan Y Cheng Xinjie X Wang Lu L Ma Dongyuan D Liu Feng F
PLoS biology 20200410 4
It is well known that various developmental signals play diverse roles in hematopoietic stem and progenitor cell (HSPC) production; however, how these signaling pathways are orchestrated remains incompletely understood. Here, we report that Rab5c is essential for HSPC specification by endocytic trafficking of Notch and AKT signaling in zebrafish embryos. Rab5c deficiency leads to defects in HSPC production. Mechanistically, Rab5c regulates hemogenic endothelium (HE) specification by endocytic tr ...[more]