White Blood Cells and Blood Pressure: A Mendelian Randomization Study.

ABSTRACT:

Background

High blood pressure (BP) is a risk factor for cardiovascular morbidity and mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic nervous system, recent experimental data suggest that immune cells may play a role in hypertension.

Methods

We studied the relationship between major white blood cell types and blood pressure in the UK Biobank population and used Mendelian randomization (MR) analyses using the ≈750 000 UK-Biobank/International Consortium of Blood Pressure-Genome-Wide Association Studies to examine which leukocyte populations may be causally linked to BP.

Results

A positive association between quintiles of lymphocyte, monocyte, and neutrophil counts, and increased systolic BP, diastolic BP, and pulse pressure was

SUBMITTER: Siedlinski M 

PROVIDER: S-EPMC7176352 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature