Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex.

ABSTRACT: Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)- and somatostatin (SST)-positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are low (<12 Hz), whereas SST interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are high (>12 Hz). Furthe

SUBMITTER: Jang HJ 

PROVIDER: S-EPMC7176419 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature