A CD24-p53 axis contributes to African American prostate cancer disparities.

ABSTRACT:

Background

Using a functional analysis of prostate cancer cells, we found a CD24-dependent inactivation of mutant p53, but the clinical significance of this observation remained uncertain. Here, we validated these results with samples of human prostate cancer and explored the role of a CD24-p53 axis in racial disparities of prostate cancer.

Methods

Samples of formalin-fixed, paraffin-embedded prostate cancer from 141 European Americans (EAs) and 147 African Americans (AAs) in two independent sample cohorts were assessed for protein expression of CD24, mutant p53, mouse double minute 2 human homolog (MDM2), and cyclin dependent kinase inhibitor 2A (ARF) using immunohistochemical analyses. All samples were analyzed for TP53^R175H and TP53^R273H .

Results

SUBMITTER: Liu W 

PROVIDER: S-EPMC7176538 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature