A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries.

ABSTRACT: Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impair neuronal differentiation and migration. Kinases of the protein kinase C (PKC) family mediate the release of growth factors that participate in different steps of the neurogenic process, particularly, novel PKC isozymes facilitate the release of the neurogenic growth factor neuregulin. We have demonstrated herein that a plant derived diterpene, (EOF2; CAS number 2230806-06-9), with the capacity to activate PKC facilitates the release of neuregulin 1, and promotes neuroblasts

SUBMITTER: Dominguez-Garcia S 

PROVIDER: S-EPMC7176668 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature