Mapping co-ancestry connections between the genome of a Medieval individual and modern Europeans.

ABSTRACT: Historical genetic links among similar populations can be difficult to establish. Identity by descent (IBD) analyses find genomic blocks that represent direct genealogical relationships among individuals. However, this method has rarely been applied to ancient genomes because IBD stretches are progressively fragmented by recombination and thus not recognizable after few tens of generations. To explore such genealogical relationships, we estimated long IBD blocks among modern Europeans, generating networks to uncover the genetic structures. We found that Basques, Sardinians, Icelanders and Orcadians form, each of them, highly intraconnected sub-clusters in a European network, indicating dense genealogical links within small, isolated populations. We also exposed individual genealogical link

SUBMITTER: Ferrando-Bernal M 

PROVIDER: S-EPMC7176696 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature