Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059.

ABSTRACT: The threat of nuclear exposure is heightened and it is imperative to identify potential countermeasures for acute radiation syndrome. Currently no countermeasures have been approved for prophylactic administration. Effective countermeasures should function to increase survival in the short term as well as to increase the overall prognosis of an exposed individual long term. Here we describe the use of a promising radiation countermeasure, BBT-059, and the results of a long term mouse study (up to 12 months) in the male CD2F1 strain using ⁶⁰Co gamma irradiation (~0.6 Gy/min, 7.5-12.5 Gy). We report the dose reduction factor of 1.28 for BBT-059 (0.3 mg/kg) compared to control administered 24 h prior to irradiation. In the long term study animals showed accelerated recovery in peri

SUBMITTER: Sharma NK 

PROVIDER: S-EPMC7176697 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature