Deficiency of CD44 prevents thoracic aortic dissection in a murine model.

ABSTRACT: Thoracic aortic dissection (TAD) is a life-threatening vascular disease. We showed that CD44, a widely distributed cell surface adhesion molecule, has an important role in inflammation. In this study, we examined the role of CD44 in the development of TAD. TAD was induced by the continuous infusion of β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, and angiotensin II (AngII) for 7 days in wild type (WT) mice and CD44 deficient (CD44^-/-) mice. The incidence of TAD in CD44^-/- mice was significantly reduced compared with WT mice (44% and 6%, p < 0.01). Next, to evaluate the initial changes, aortic tissues at 24 hours after BAPN/AngII infusion were examined. Neutrophil accumulation into thoracic aortic adventitia in CD44^-/- mice was significantly decrea

SUBMITTER: Hatipoglu OF 

PROVIDER: S-EPMC7176701 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature