Probabilistic estimates of prenatal lead exposure at 195 toxic hotspots in low- and middle-income countries.

ABSTRACT:

Background

Prior estimates of pediatric lead-related disease burden in low- and middle-income countries (LMICs) used population estimates of maternal blood lead levels (BLLs). This approach may underestimate fetal BLLs by not considering potentially high prenatal lead exposure from toxic hotspots_. OBJECTIVES: We developed a probabilistic approach to using the Adult Lead Methodology (ALM) to estimate fetal BLLs from prenatal exposure to lead-contaminated soil at hotspots in the Toxic Site Identification Program (TSIP).

Methods

We created distributions for each ALM parameter using published literature and extracted soil lead measurements from the TSIP database. Each iteration of the probabilistic ALM randomly selected values from the input distributions to generate

SUBMITTER: Zajac L 

PROVIDER: S-EPMC7176741 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature