Comparison effects of olive leaf extract and oleuropein compounds on male reproductive function in cyclophosphamide exposed mice.

ABSTRACT: Spermatogenesis is a complicated process in which sperm is susceptible to various chemotherapy drugs such as cyclophosphamide (CP). As olive leaf extract (OLE) and its active ingredient, oleuropein, have variousantioxidant, anti-apoptotic, and anti-inflammatory properties the aim of the present study was to investigate the effects of OLE and oleuropein on male reproductive function focusing antioxidative effects and histological modifications in the testes of CP-exposed mice. In order to do this, 80 NMRI male mice were divided into eight groups including control group, group received CP, group received OLE, group received oleuropein, group received OLE following CP exposure, group received oleuropein following CP exposure, group received OLE plus oleuropein and group received OLE plus oleu

SUBMITTER: Rostamzadeh A 

PROVIDER: S-EPMC7176941 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature