Multidirectional wall shear stress promotes advanced coronary plaque development: comparing five shear stress metrics.

ABSTRACT:

Aims

Atherosclerotic plaque development has been associated with wall shear stress (WSS). However, the multidirectionality of blood flow, and thus of WSS, is rarely taken into account. The purpose of this study was to comprehensively compare five metrics that describe (multidirectional) WSS behaviour and assess how WSS multidirectionality affects coronary plaque initiation and progression.

Methods and results

Adult familial hypercholesterolaemic pigs (n = 10) that were fed a high-fat diet, underwent imaging of the three main coronary arteries at three-time points [3 (T1), 9 (T2), and 10-12 (T3) months]. Three-dimensional geometry of the arterial lumen, in combination with local flow velocity measurements, was used to calculate WSS at T1 and T2. For analysis, arteries were di

SUBMITTER: Hoogendoorn A 

PROVIDER: S-EPMC7177495 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature