A TREML2 missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects.

ABSTRACT:

Introduction

Triggering receptor expressed on myeloid cells-like transcript 2 gene (TREML2) is a newly identified AD susceptibility gene. Its missense variant rs3747742-C substantially decreases AD risk in both Caucasians and Han Chinese, but the underlying mechanisms remain elusive. In the present study, to uncover the possible mechanisms by which TREML2 rs3747742-C reduces AD risk, we investigated the possible relation of this variant with AD-related brain structures using a cognitively normal elderly population from Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

Methods

In total, 158 cognitively normal elders from ADNI database with complete data for brain structures and TREML2 rs3747742 genotype were included in this study. The association of TREML2 rs37477

SUBMITTER: Wang SY 

PROVIDER: S-EPMC7177563 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature