The course of recovery of locomotor function over a 10-week observation period in a rat model of femoral nerve resection and autograft repair.

ABSTRACT:

Background

A great extent of knowledge on peripheral nerve regeneration has been gathered using the rat sciatic nerve model. The femoral nerve model of the rat offers an interesting alternative, as it lacks disadvantageous features such as automutilation. For the analysis of locomotor behavior in rats after sciatic nerve injury, the CatWalk^™ XT Gait Analysis System is often used. However, lesions of the femoral nerve in the rat have yet remained unstudied with this method.

Material and methods

Ten male Sprague Dawley rats were evaluated with the CatWalk XT to study their gait after a 6-mm resection of the right femoral nerve and reconstruction with an autologous nerve graft. Animals were observed for 10 weeks after surgery.

Results

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SUBMITTER: Heinzel JC 

PROVIDER: S-EPMC7177579 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature